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Chemosensors
Special Issues
Biological and Chemical Sensors Applied in Biopharmaceuticals
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Biological and Chemical Sensors Applied in Biopharmaceuticals

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Applied Chemical Sensors".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1633

Special Issue Editor

Dr. Brian D. Plouffe

E-Mail Website
Guest Editor
Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI, USA
Interests: biotechnology; microfluidics; affinity chromography; therapeutics and diagnostics

Special Issue Information

Dear Colleagues,

The biopharmaceutical industry has traditionally utilized batch manufacturing strategies for production, but continuous manufacturing has been explored as an alternative production method in recent years because of the potential financial and quality benefits. The complex nature of this manufacturing method requires the development at scale of sensors that can monitor and control production at commercial scale.  Additionally, throughout the manufacturing process validation of the product is required for safety and efficacious drug products; as drug complexity increases quality control will require new advance sensor approaches. The sensor developments must also adhere to strict regulatory guidelines. The topics explored in this Special Topics will describe both established and new sensor technologies for characterizing and monitoring biopharmaceutical product, both upstream and downstream.  Both review and original research articles are welcomed from a broad spectrum of disciplines such as physics, chemistry, biochemistry, medicine, analytical science, materials science, and engineering to highlight the latest developments and future challenges in this exciting field.

Dr. Brian D. Plouffe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • single-use biopharmaceutical manufacturing
  • radio-frequency identification (RFID)-based sensing
  • process analytical technologies
  • spectroscopy
  • chemometrics
  • downstream processing
  • upstream processing
  • biologics

Published Papers (1 paper)

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Review

58 pages, 10512 KiB  
Review
Electrochemical Sensors, Biosensors, and Optical Sensors for the Detection of Opioids and Their Analogs: Pharmaceutical, Clinical, and Forensic Applications
by Sayo O. Fakayode, Pamela Nicole Brady, Cidya Grant, Vivian Fernand Narcisse, Peter Rosado Flores, Catrena Higginbothan Lisse and David K. Bwambok
Chemosensors 2024, 12(4), 58; https://doi.org/10.3390/chemosensors12040058 - 08 Apr 2024
Viewed by 1059
Abstract
Pharmaceutical opioids are intravenously or orally administered analgesics. While they are effective in relieving chronic and acute pain, their narrow window of therapeutic use contributes to the high occurrence of abuse. The associated abuse of this family of drugs can be correlated to [...] Read more.
Pharmaceutical opioids are intravenously or orally administered analgesics. While they are effective in relieving chronic and acute pain, their narrow window of therapeutic use contributes to the high occurrence of abuse. The associated abuse of this family of drugs can be correlated to the increase in dependency, overdose, and death of users. The negative effects of opioids extend beyond the physical and psychological effects experienced by the user to their unregulated synthesis and sale, which contribute to socioeconomic challenges and are a biproduct of this global public health epidemic. From clinical to point-of-care applications, the detection and real-time monitoring of this family of drug is critical in the fight to decrease abuse and improve use in clinical settings. Chromatographic separations and chromatography–mass spectrometry are traditional methods of opioid analyses, but the high cost, long analysis time, and absence of portability highlight the need for the development of fast, in situ, point-of-care analysis, or of community drug monitoring services. This review highlights recent electrochemical and optical (FTIR, Raman, colorimetric, and fluorescent) advances and biosensors for pharmaceutical and illicit opioid analysis. Specifically, an emphasis is placed on the detection of opioids and their metabolites in biological samples and in vitro cellular assays for clinical diagnosis and forensic applications. The challenges and prospects of the role of electrochemical sensors, biosensors, and optical sensors for opioid analysis in promoting clinical diagnosis, forensic study, point-of-care, and community drug monitoring services to reduce harm are also provided. Full article
(This article belongs to the Special Issue Biological and Chemical Sensors Applied in Biopharmaceuticals)
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