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Applications of Chemosensors in Real-World Sample Analysis

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A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Applied Chemical Sensors".

Deadline for manuscript submissions: closed (10 May 2022) | Viewed by 13126

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Special Issue Editors

Dr. Run Zhang

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Guest Editor

Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane 4072, Australia
Interests: analytical chemistry; biosensing and bioimaging; photochemistry; nanotechnology; nano-bio interface chemistry; nanobiosensors; theranostic nanomaterials
Special Issues, Collections and Topics in MDPI journals

Dr. Xiupei Yang

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Guest Editor

College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637000, China
Interests: chemosensors; biosensors; nanoprobes; analytical methods

Dr. Yinyin Bao

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Guest Editor

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Sciences, ETH Zurich, 8093 Zurich, Switzerland
Interests: fluorescent chemosensors; nanosensors; bioimaging; drug delivery; nanomedicine; fluorescent polymers; biodegradable polymers; 3D printing; medical devices
Special Issues, Collections and Topics in MDPI journals

Dr. Suban K. Sahoo

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Guest Editor

Department of Applied Chemistry, S.V. National Institute of Technology (SVNIT), Surat-395007, Gujarat, India
Interests: supramolecular chemistry and molecular recognition; fluorescent and colorimetric chemosensors; sensors based on optically active nanomaterials

Special Issue Information

Dear Colleagues,

The advances of analytical science heavily rely on the development of new methods for precise and accurate analyte detection in a specific biological, pharmaceutical, environmental, agricultural, and food system. Of various methods, chemosensors have been recognized as one of the most powerful tools and technologies in the analysis of various markers in real-world samples. These markers include small and macro-biomolecules, ions, pathogens, pesticide residues, and pollutants. The chemosensors are generally designed by incorporating analyte-responsive units into molecular and nanoscale signaling scaffold (receptor), such as chromophores, luminophores, and contrast agents. The recognition interaction/binding/reaction between the analyte and sensors gives rise to a change of the receptor’s signal that can be recorded for the quantitative analysis of this analyte. Due to the high sensitivity and specificity, fast response, simplicity, and relatively non-invasive nature, the chemosensors have found many applications for the quantitative sensing trace of amounts of analytes in the aforementioned systems. In this context, this Special Issue “Applications of Chemosensors in Real-World Sample Analysis” of Chemosensors is a forum for research outcomes and ideas in this field.

This Special Issue will collect a series of high-quality papers focused on new sensor development and applications in analytical science. Contributions including original research papers, up-to-date reviews, and perspectives of the aforementioned topics are invited.

Dr. Run Zhang
Dr. Xiupei Yang
Dr. Yinyin Bao
Dr. Suban K. Sahoo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Chemosensors
chemodoisomers
biosensors
nanosensors
contrast agents
analytical methods
responsive polymers
molecular recognition
real-world samples

Published Papers (5 papers)

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Research

17 pages, 3293 KiB

Open AccessArticle

Rapid Voltammetric Screening Method for the Assessment of Bioflavonoid Content Using the Disposable Bare Pencil Graphite Electrode

by Iulia Gabriela David, Nimet Numan, Mihaela Buleandră, Dana-Elena Popa, Simona Carmen Lițescu, Sorin Riga and Adela Magdalena Ciobanu

Chemosensors 2021, 9(11), 323; https://doi.org/10.3390/chemosensors9110323 - 18 Nov 2021

Cited by 8 | Viewed by 1576

Abstract

Hesperidin (HESP) is a plant bioflavonoid found in various nutritional and medicinal products. Many of its multiple health benefits rely on the compound’s antioxidant ability, which is due to the presence of oxidizable hydroxyl groups in its structure. Therefore, the present study aimed to investigate the electrochemical behavior of HESP at a cheap, disposable pencil graphite electrode (PGE) in order to develop rapid and simple voltammetric methods for its quantification. Cyclic voltammetric investigations emphasized a complex electrochemical behavior of HESP. The influence of the electrode material, solution stability, supporting electrolyte pH, and nature were examined. HESP main irreversible, diffusion-controlled oxidation signal obtained at H type PGE in Britton Robinson buffer pH 1.81 was exploited for the development of a differential pulse voltammetry (DPV) quantitative analysis method. The quasi-reversible, adsorption-controlled reduction peak was used for HESP quantification by differential pulse adsorptive stripping voltammetry (DPAdSV). The linear ranges of DPV and DPAdSV were 1.00 × 10⁻⁷–1.20 × 10⁻⁵ and 5.00 × 10⁻⁸–1.00 × 10⁻⁶ mol/L with detection limits of 8.58 × 10⁻⁸ and 1.90 × 10⁻⁸ mol/L HESP, respectively. The DPV method was applied for the assessment of dietary supplements bioflavonoid content, expressed as mg HESP. Full article

(This article belongs to the Special Issue Applications of Chemosensors in Real-World Sample Analysis)

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Graphical abstract

20 pages, 5024 KiB

Open AccessArticle

Evaluating the Effect of a Brewery By-Product as Feed Supplementation on the Quality of Eggs by Means of a Human Panel and E-Tongue and E-Nose Analysis

by Juan Pablo Aguinaga Bósquez, Zoltan Kovacs, Zoltán Gillay, György Bázár, Csaba Palkó, Hajnalka Hingyi, Éva Csavajda, Márta Üveges, Zsuzsanna Jókainé Szatura, Iuliana Diana Barbulescu, Mihaela Begea and Tamás Tóth

Chemosensors 2021, 9(8), 213; https://doi.org/10.3390/chemosensors9080213 - 06 Aug 2021

Cited by 8 | Viewed by 2566

Abstract

The objective of our research was to evaluate the possible alteration of the organoleptic properties of eggs produced by hens (Lohmann Brown-Classic) fed with diets containing different doses of an industrial by-product enriched with organic zinc (Zincoppyeast, ZP): Control 0%, ZP 2.5%, and ZP 5.0%. Eggs were collected after 30 days (batch 1) and 60 days (batch 2) of feeding with the experimental diets and subjected to chemical, microbiological, human sensory, e-nose, and e-tongue analyses. There was no significant difference among the microbiological status of eggs of the three groups, but there were significant differences (p < 0.05) in the fat (9.5% vs. 9.3%) and protein contents (12.7% vs. 13.4%) of the Control and ZP 5.0% groups, respectively. Human sensory analysis showed no clear change in the organoleptic characteristics of the eggs. Using linear discriminant analysis (LDA), the e-tongue could recognize the three groups of eggs in batch 1 and batch 2 with 95.9% and 100% accuracy and had a prediction accuracy of 64.8% and 56.2%, respectively. When the eggs were incubating at 50 °C or 80 °C before the e-nose analysis, the groups of eggs could be recognized with 98.0% and 82.7% accuracy, and predicted with 68.5% and 62.2% accuracy, respectively, using principal component analysis-based discriminant analysis (PCA–DA). The aroma compounds and respective sensory descriptors showing changes among the different groups of eggs (batch, storage, and feeding) were identified based on the e-nose analysis. The supplementation of laying hens’ feed with the investigated industrial by-product can be applied without any substantial effect on egg quality, which can, however, be detected with advanced analytical methods. Full article

(This article belongs to the Special Issue Applications of Chemosensors in Real-World Sample Analysis)

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18 pages, 3026 KiB

Open AccessArticle

Multi-Sensor Characterization of Sparkling Wines Based on Data Fusion

by Anais Izquierdo-Llopart and Javier Saurina

Chemosensors 2021, 9(8), 200; https://doi.org/10.3390/chemosensors9080200 - 30 Jul 2021

Cited by 7 | Viewed by 1875

Abstract

This paper is focused on the assessment of a multi-sensor approach to improve the overall characterization of sparkling wines (cava wines). Multi-sensor, low-level data fusion can provide more comprehensive and more accurate vision of results compared with the study of simpler data sets from individual techniques. Data from different instrumental platforms were combined in an enriched matrix, integrating information from spectroscopic (UV/Vis and FTIR), chromatographic, and other techniques. Sparkling wines belonging to different classes, which differed in the grape varieties, coupages, and wine-making processes, were analyzed to determine organic acids (e.g., tartaric, lactic, malic, and acetic acids), pH, total acidity, polyphenols, total antioxidant capacity, ethanol, or reducing sugars. The resulting compositional values were treated chemometrically for a more efficient recovery of the underlaying information. In this regard, exploratory methods such as principal component analysis showed that phenolic compounds were dependent on varietal and blending issues while organic acids were more affected by fermentation features. The analysis of the multi-sensor data set provided a more comprehensive description of cavas according to grape classes, blends, and vinification processes. Hierarchical Cluster Analysis (HCA) allowed specific groups of samples to be distinguished, featuring malolactic fermentation and the chardonnay and red grape classes. Partial Least Squares-Discriminant Analysis (PLS-DA) also classified samples according to the type of grape varieties and fermentations. Bar charts and complementary statistic test were performed to better define the differences among the studied samples based on the most significant markers of each cava wine type. As a conclusion, catechin, gallic, gentisic, caftaric, caffeic, malic, and lactic acids were the most remarkable descriptors that contributed to their discrimination based on varietal, blending, and oenological factors. Full article

(This article belongs to the Special Issue Applications of Chemosensors in Real-World Sample Analysis)

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15 pages, 16377 KiB

Open AccessArticle

A Deferasirox Derivative That Acts as a Multifaceted Platform for the Detection and Quantification of Fe³⁺

by Axel Steinbrueck, Adam C. Sedgwick, Suh-Mi Hwang, Sajal Sen, Michael Y. Zhao, Dan-Ying Huang, Daniel M. Knoll, Yu-Ying Wang and Jonathan L. Sessler

Chemosensors 2021, 9(4), 68; https://doi.org/10.3390/chemosensors9040068 - 30 Mar 2021

Cited by 1 | Viewed by 3073

Abstract

Here, we report that ExSO₃H, a synthetically accessible, water-soluble, non-toxic derivative of the clinical iron chelator deferasirox, acts as a colorimetric chemosensor that permits the detection and quantification of Fe³⁺ in aqueous samples at pH 2–5. In addition, we observed that a fluorescent turn-on response was produced when this chelator was allowed to interact with human serum albumin (HSA). This fluorescence was quenched in the presence of Fe³⁺, thus allowing us to monitor the presence of this biologically important metal cation via two independent methods. Full article

(This article belongs to the Special Issue Applications of Chemosensors in Real-World Sample Analysis)

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16 pages, 2292 KiB

Open AccessArticle

Potentiometric Carbon Quantum Dots-Based Screen-Printed Arrays for Nano-Tracing Gemifloxacin as a Model Fluoroquinolone Implicated in Antimicrobial Resistance

by Miriam F. Ayad, Yossra A. Trabik, Mona H. Abdelrahman, Nermine V. Fares and Nancy Magdy

Chemosensors 2021, 9(1), 8; https://doi.org/10.3390/chemosensors9010008 - 31 Dec 2020

Cited by 9 | Viewed by 2589

Abstract

Antimicrobial resistance (AMR) is a neglected issue that poses a serious global threat to public health, causing long-term negative consequences at both humanitarian and economic levels. Herein, we report an unprecedented economic fabrication method of seven potentiometric screen-printed sensors for the ultra-trace determination of gemifloxacin (GEMI) as a model of the fluoroquinolones antibiotics deeply involved in the growing AMR problem. Sensors were constructed by depositing homemade carbon ink on a recycled X-ray sheet, patterned using stencils printed with an office printer in simple, cost-effective steps requiring no sophisticated equipment. Four sensors were modified using carbon quantum dots (CQDs) synthesized from dextrose through a single-step method. Sensors exhibited a linear response in the concentration ranges 10⁻⁵–10⁻² M (sensors 1, 3 and 4), 10⁻⁶–10⁻³ M (sensor 2) and 10⁻⁶–10⁻² M (sensors 5, 6 and 7). LOD allowed tracing of the target drug at a nano-molar level down to 210 nM. GEMI was successfully determined in pharmaceutical formulations and different water samples without any pretreatment steps with satisfactory recovery (96.93–105.28% with SD values < 3). All sensors revealed a long lifetime of up to several months and are considered promising tools for monitoring water quality and efficiency of water treatment measures. Full article

(This article belongs to the Special Issue Applications of Chemosensors in Real-World Sample Analysis)

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