Primary Sjögren Syndrome: Diagnosis and Management

Dear Colleagues,

In the past few years, many intriguing novelties in the field of Sjögren’s syndrome have emerged. Beyond its pathogenesis, wherein we are getting closer and closer to the understanding of the initial steps of the disease, both the diagnosis and comprehensive management of Sjögren’s syndrome have achieved revolutionary milestones.

Regarding diagnosis, we should make efforts towards less invasive modalities. While minor salivary gland biopsy is still a gold—although not obligatory—standard of the diagnostic pathway, future classifications should focus on the use of accurate biomarkers and preserve histology for prognostic measures. Given the relatively high prevalence among systemic autoimmune diseases, perhaps it is time to consider a validation of diagnostic criteria instead of classification criteria.

The management of Sjögren’s syndrome extends far beyond prescribing artificial tears and saliva and systemic disease-modifying drugs. Thanks to the well-educated patient society, we can make shared decisions, and, with the help of patient reported outcome measures and their easy use on mobile phone applications, patients and physicians are finally able to speak a common language regarding disease activity and disease burden. There are several promising new drug developments in the pipeline that will hopefully help patients to live a full life—not only free of systemic disease activity but free of devastating sicca symptoms as well.

These topics will be discussed throughout this Special Issue.

Dr. Antónia Szántó
Guest Editor

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• Sjögren’s syndrome
• disease burden
• biomarkers
• comprehensive management