Latest Imaging Researches on Movement Disorders

Dear Colleagues,

Neuroimaging is more and more often considered a decisive role in the field of movement disorders, both in regard to the diagnostic definition of the different clinical entities and as a role of a possible biomarker of disease progression. This has been possible thanks to the spread of increasingly sophisticated structural neuroimaging techniques such as 7 Tesla brain MRI, functional neuroimaging techniques such as PET/MRI, or the use of new ligands such as the tau or alpha-synuclein ones.

This technological development has gone hand in hand with developments in the field of genetics in movement disorders with the identification and clinical characterization of multiple gene variants associated with parkinsonism, dystonia, or ataxia.

It is, therefore, interesting to research the presence of neuroimaging characteristics within different genetic forms of movement disorders to obtain both a more precise diagnostic classification but also to characterize these entities not only from a clinical point of view but even from an instrumental point of view.

This appears to be extremely important alongside the recent development of clinical trials focused on the different genetic forms of Parkinson's disease (i.e., LRRK2 and GBA genes).

The purpose of this Special Issue is to investigate the latest imaging research on movement disorders, with a particular focus on the correlation with genetics, both in regard to the phenotypic characterization and for the identification of biomarkers of disease progression.

Dr. Francesco Cavallieri
Dr. Eleonora Del Prete
Guest Editors

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• movement disorders
• brain magnetic resonance imaging (MRI)
• MRI spectroscopy
• MRI tractography
• 7 Tesla MRI
• SPECT imaging with DaTSCAN ((123)I-Ioflupane)
• [18F]FDG-PET
• amyloid-β PET
• tau PET tracers
• alpha-synuclein PET tracers
• fluorodopa PET scanning
• genetics
• ataxia
• parkinson's disease
• parkinsonism
• chorea
• dystonia
• progressive supranuclear palsy
• multiple system atrophy
• LRRK2
• GBA
• SNCA