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A Score for Predicting Freedom from Progression of Children and Adolescents with Hodgkin Lymphoma
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Valli De Re, Laura Caggiari, Maurizio Mascarin, Mariangela De Zorzi, Caterina Elia, Ombretta Repetto, Lara Mussolin, Marta Pillon, Paola Muggeo, Salvatore Buffardi, Maurizio Bianchi, Alessandra Sala, Luciana Vinti, Piero Farruggia, Elena Facchini, Egesta Lopci, Emanuele S. G. d’Amore, Roberta Burnelli and with the A.I.E.O.P. Consortium
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Abstract
Several studies have examined the prognostic performance of therapeutic groups (TG) and early responses to therapy on positron emission tomography/computed tomography (PET/CT) in children and adolescents with classical Hodgkin lymphoma (cHL); less research has been performed on molecular parameters at diagnosis. The aim
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Several studies have examined the prognostic performance of therapeutic groups (TG) and early responses to therapy on positron emission tomography/computed tomography (PET/CT) in children and adolescents with classical Hodgkin lymphoma (cHL); less research has been performed on molecular parameters at diagnosis. The aim of the present study was to devise a scoring system based on the TG criteria for predicting freedom from progression (FFP) in 133 patients: 63.2% males; 14 years median age (interquartile range (IQR) 11.9–15.1); with cHL (108 nodular sclerosis (NS) subtype) treated according to the AIEOP LH-2004 protocol; and median 5.55 (IQR 4.09–7.93) years of follow-up. CHL progressed or relapsed in 37 patients (27.8%), the median FFP was 0.89 years (IQR = 0.59–1.54), and 14 patients (10.5%) died. The FPR (final prognostic rank) model associates the biological HLA-G SNP 3027C/A (numerical point assigned (pt) = 1) and absolute neutrophil count (>8 × 10
9/L, pt = 2) as variables with the TG (TG3, pt = 3). Results of FPR score analyses for FFP suggested that FPR model (Kaplan–Meier curves, log-rank test for trends) was better than the TG model. At diagnosis, high-risk patients classified at FPR rank 4 and 5 identified 18/22 patients who relapse during the follow-up.
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(This article belongs to the Section
Lymphomas)
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