Special Issue Editors

Dr. Yuriy Alekseyev

E-Mail Website
Guest Editor

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Interests: microarrays; next generation sequencing; genomics; genomics technologies; gene expression; RNA-seq; translational research

Dr. Gang Liu

E-Mail Website
Guest Editor

Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Interests: translational research; lung disease; genomics technologies; microarrays; next generation sequencing; RNA-seq; gene expression

Special Issue Information

Dear Colleagues,

Various chemical, biological, radioactive, and physical agents dramatically affect human health upon acute or chronic exposure. This Special Issue will focus on studies of environmental agents in various model systems and in the epidemiological and clinical settings that use whole genome approaches, including technologies, such as microarrays and next generation sequencing. The major goal of this Special Issue will be to expand our knowledge regarding the spectrum of hazardous environmental agents, their mechanisms of action, as well as prevention of their harmful effects, on human populations. Special emphasis will be given to carcinogens, but we would encourage submission of articles addressing any relevant environmental agent. Original research articles using whole genome approaches, as well as systematic reviews and or meta-analyses of published data, are welcome.

Dr. Yuriy Alekseyev
Dr. Gang Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. High-Throughput is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Related Special Issue

Published Papers (1 paper)

Review

23 pages, 742 KiB

Open AccessReview

Genomics and Epigenetics of Malignant Mesothelioma

by Adam P. Sage, Victor D. Martinez, Brenda C. Minatel, Michelle E. Pewarchuk, Erin A. Marshall, Gavin M. MacAulay, Roland Hubaux, Dustin D. Pearson, Aaron A. Goodarzi, Graham Dellaire and Wan L. Lam

High-Throughput 2018, 7(3), 20; https://doi.org/10.3390/ht7030020 - 27 Jul 2018

Cited by 32 | Viewed by 7630

Abstract

Malignant mesothelioma is an aggressive and lethal asbestos-related disease. Diagnosis of malignant mesothelioma is particularly challenging and is further complicated by the lack of disease subtype-specific markers. As a result, it is especially difficult to distinguish malignant mesothelioma from benign reactive mesothelial proliferations or reactive fibrosis. Additionally, mesothelioma diagnoses can be confounded by other anatomically related tumors that can invade the pleural or peritoneal cavities, collectively resulting in delayed diagnoses and greatly affecting patient management. High-throughput analyses have uncovered key genomic and epigenomic alterations driving malignant mesothelioma. These molecular features have the potential to better our understanding of malignant mesothelioma biology as well as to improve disease diagnosis and patient prognosis. Genomic approaches have been instrumental in identifying molecular events frequently occurring in mesothelioma. As such, we review the discoveries made using high-throughput technologies, including novel insights obtained from the analysis of the non-coding transcriptome, and the clinical potential of these genetic and epigenetic findings in mesothelioma. Furthermore, we aim to highlight the potential of these technologies in the future clinical applications of the novel molecular features in malignant mesothelioma. Full article

(This article belongs to the Special Issue Whole-Genome Approaches to Study Environmental Exposures)

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