Advances in the Diagnosis and Management of Renal Diseases
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 10974
Special Issue Editors
Interests: kidney stones; arterial hypertension; renal hypertension; urination disorders; cysts nephropathy; glomerulonephritis; proteinuria, hematuria; diabetic kidney disease; polycystic kidney disease; urinary tract infections; cystitis; pyelonephritis; chronic kidney disease; transplant kidney; renal failure; edema; acidosis; metabolic disorders; hyperparathyroidism; nephrocalcinosis; abnormal GFR
Special Issues, Collections and Topics in MDPI journals
Interests: acute kidney injury; biomarkers in nephrology; CAKUT; obstructive uropathy; vesico-ureteral reflux; hemolytic uremic syndrome; idiopathic/congenital/infantile nephrotic syndrome; primary glomerulopathies; chronic kidney disease; hemodialysis; peritoneal dialysis; transition medicine; hypertension
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The last decade has seen a number of advances in the diagnostics and management of glomerulopathies, interstitial and hypertensive nephropathy, kidney stone disease, vasculitis, and diabetic kidney disease.
Since the progressive loss of functioning renal tissue may result from a number of different disturbances (congenital hypoplasia or obstructive uropathy with or without associated infections, other anomalies, polycystic kidneys, chronic pyelonephritis, glomerulonephritis, etc.), an exact diagnosis is essential for the establishment of appropriate therapy.
With a few exceptions, invasive diagnostics—namely, a kidney biopsy—are currently required for the precise diagnosis of many chronic kidney diseases. In order to effectively develop personalized medicine for renal diseases, we urgently need to develop highly accurate biomarkers for use in the clinic, since the current biomarkers of kidney damage (creatinine and/or urine albumin excretion) apply to later stages of the disease. A promising non-invasive approach is urinary proteome analysis, which has the potential to identify various types of renal disease. Renal failure, a consequence of renal disease progression, is among the most deadly and economically costly diseases faced by patients and modern society. Despite this, there are relatively few new therapies in development for the treatment of renal disease. Multiple factors have contributed to the diminishing interest in pharmaceutical investment for the field of renal disease: many costly phase 3 trials have failed to provide improved renal outcomes, and the awareness of renal diseases remains poor among patients, physicians, and payers. Nevertheless, several therapeutics remain in development for the treatment of CKD, including mineralocorticoid-receptor antagonists, sodium/glucose cotransporter 2 inhibitors, anti-inflammatory drugs, and drugs that mitigate oxidative injury.
The success of the future management of renal disease will depend not only on an improved understanding of disease pathogenesis but also on increasing the awareness of this disease among the public and the greater medical community, as well as quick diagnostics and appropriate treatment.
Prof. Dr. Mariusz A. Kusztal
Prof. Dr. Kinga Musiał
Guest Editors
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Keywords
- chronic kidney disease
- glomerulonephritis
- biomarkers
- kidney biopsy
- treatment
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