Transcriptional Regulation and Targeted Therapy in Cancer

Dear Colleagues,

The extensive use of transcriptome technologies has rapidly advanced our knowledge on differential gene expression, alternative splicing modulation and RNA editing, which are used to identify differences between several types of cancers and corresponding normal tissues. However, the weight of such dysregulations in determining cancer hallmarks and their relevance as pharmacological targets are not simply and linearly related to the entity of transcriptional dysregulation. Indeed, the application of different techniques for the modulation of gene expression, such as siRNAs and CRISR/Cas9, coupled to biochemical and biological assays related to cancer hallmarks, can be considered crucial tools to clarify which transcriptional dysregulations are involved in cancer pathogenesis. This Special Issue is dedicated to the description of such efforts, to the identification of novel actionable transcriptional dysregulations and to the preclinical set-up of novel transcript-targeted anticancer therapies.

Prof. Dr. Daniele Filippo Condorelli
Guest Editor

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• transcript-targeted therapies
• cancer
• siRNA
• ASO
• CRISPR/Cas9