Signaling Transduction in Health and Disease

Dear Colleagues,

Signaling transduction stands at the core of maintaining cellular equilibrium. The intricate networks of communication within cells and their interactions with the extracellular environment demand a meticulous exploration of signaling mechanisms, spanning both macromolecular and nanoscale levels, to grasp their intricate workings. In recent decades, remarkable strides have been taken in this field, revealing a diverse spectrum of signaling mechanisms and their nuanced regulation within cells. These signaling pathways stretch from the extracellular milieu, traversing the plasma membrane, reaching various organelles, facilitating intra-organellar communication, and triggering specific cellular responses. This complexity underscores the necessity for a comprehensive investigation into signaling processes, illuminating their multifaceted roles in both health and disease. In particular, cytokines, chemokines, and endotoxins have been implicated in the pathogenesis of various inflammatory diseases, mediated through the activation of various intracellular signaling components and transcription factors, leading to the expression of inflammatory proteins such as cytokines, chemokines, adhesion molecules, etc. Through collaborative endeavors, our objective is to unravel the intricacies of signal transduction, offering profound insights that have the potential to revolutionize therapeutic strategies and advance human health. This Special Issue is dedicated to exploring signaling transduction in diverse cells and tissues, both in health and disease. These roles encompass a complex array of effects on gene expression modulation, profoundly impacting the development and progression of disorders in the endocrine, cardiovascular, respiratory, gastrointestinal, nervous, and immune systems, as well as various malignancies.

Dr. Chuen-Mao Yang
Dr. I-Ta Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• signaling pathways
• inflammation
• human disease
• oxidative stress
• neurodegeneration
• heart disease
• antioxidants