Reprogramming in Cardiac Tissue

Dear Colleagues,

Cardiovascular diseases are still a leading cause of mortality in developed countries with highly limited therapy options. Thereby, the very limited regeneration potential of collapsed cardiomyocytes is a major treatment obstacle. Therefore, novel approaches toward personalized regenerative therapy and drug development have gained increasing importance. Over the last two decades, the forward programming of iPSCs and the Direct Reprogramming of somatic cells and adult stem cells have introduced entirely novel options for improving cardiovascular regenerative medicine based on autologous cells as a treatment source. Thereby, knowledge from developmental biology has led to master regulator combinations, redefining cellular fates. In particular, direct somatic cell reprogramming towards cardiovascular cells while avoiding a potentially teratogenic pluripotency state is expected to gain great importance. Moreover, in vitro testing utilizing organoid cultures derived from patient-specific programmed cardiovascular cells will likely enable personalized drug testing in precision medicine. This Special Issue will broadly address topics from the basic science of somatic and stem cell reprogramming to their applications in cardiovascular regeneration and disease treatment, as well as novel pathways toward cardiovascular in vitro disease modeling.

This Special Issue accepts original studies, reviews and technical reports in the field of cardiovascular cell programming, disease modeling and cell-based therapy written by scientists active in the field.

Prof. Dr. Robert David
Guest Editor

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• cardiac tissue
• cardiovascular cell programming
• myocardial development
• cardiac regeneration
• cardiomyocyte proliferation
• cell-based therapy
• pluripotent stem cells
• iPSCs