Molecular Advances and Insights on Diagnosis, Prevention and Therapeutics of Cardiovascular Diseases

Dear Colleagues,

Cardiovascular diseases (CVDs) comprising a group of disorders of the heart and blood vessels, including coronary heart disease, stroke, peripheral arterial, and aortic disease, are the leading cause of morbidity and mortality globally with high prevalence in our aging society. Atherosclerosis is the leading cause of CVDs and cardiovascular-related death worldwide. Numerous pathological processes and molecular factors have been implicated in the development and progression of atherosclerosis including inflammation, vascular calcification, endothelial dysfunction, and oxidative stress.

Cardiovascular calcification caused by the deposition of calcium mineral in the vascular tree represents an increased risk of cardiovascular events and is associated with several vascular disease processes, not only in the intima associated with atherosclerosis, but also in the media layer highly prevalent in chronic kidney disease (CKD) and diabetic patients, and in cardiac valves associated with calcific valvular diseases.

A better understanding of the pathophysiological and molecular mechanisms involved at the genesis of these complex set of diseases, with a particular emphasis on inflammation and calcification processes, will bring new opportunities to explore novel biomarkers and therapeutic targets for CVD.

We are pleased to invite you to submit to this Special Issue on “Molecular Advances and Insights on Diagnosis, Prevention and Therapeutics of Cardiovascular Diseases”.

We will welcome original or review articles. Research areas may include (but not be limited to) the following: biomarkers; therapeutic targets, oxidative stress; inflammation, pathological calcification, cardiovascular calcification, atherosclerosis, chronic kidney disease, diabetes; obesity; diet supplements.

This Special Issue will include novel knowledge on biomedical science and translational research in order to comprehensively study and bring novel insights on the molecular aspects, the pathophysiology, the prevention, and therapeutic alternatives for this complex set of multifactorial diseases.

Dr. Dina Costa Simes
Dr. Carla Viegas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cardiovascular disease
• cardiovascular calcification
• inflammation
• oxidative stress
• atherosclerosis
• chronic kidney disease
• endothelial dysfunction