Cellular Stress and Genomics in Eukaryotes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1071
Special Issue Editor
Special Issue Information
Dear Colleagues,
Genomic instability is a major cause of cancer cell formation in multicellular organisms and is one criterion for the diagnosis of cancer, as a significant proportion of mutations leading to tumourigenesis can be caused by the dysregulation of the mechanisms responsible for normal DNA segregation in mitosis. The regulatory systems of these processes impose different metabolic specificities on each phase of the cell cycle and, by supervising the correct chronology of events, condition the maintenance of the structural and functional integrity of the eu- and heterochromatin sequences.
The effect of many chemical agents can be to 'bypass' (overriding) or disrupt the surveillance of genome integrity. The course of the subsequent phases of nuclear division is then aberrant and can lead to cell death. Disabling the function of internal S-phase checkpoints leads to the sensitisation of tumour cells to anticancer agents and the effects of ionising radiation. It represents not only an important fundamental problem in cell cycle biology, but also an important issue in terms of potential medical applications.
We invite the submission of studies related to the molecular dynamics of replication and mitosis and cellular stress in eukaryotic cells. Since IJMS is a journal of molecular science, pure clinical studies will not suitable for our journal. However, clinical or pure model submissions with biomolecular experiments are welcome.
Dr. Dorota Rybaczek
Guest Editor
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Keywords
- genomic instability
- chromosomal instability
- premature mitoses
- premature chromosome condensation
- cell death
- replication stress
- DNA damage
- cell cycle checkpoints
- synthetic lethality
- chromothripsis
- eukaryotic cells