Chronic Hypoxia and Inflammation in Human Pathology

Dear Colleagues,

We are becoming increasingly aware (see Pubmed) that the association of hypoxia with inflammation (the HIF/NFkB pathway and similar) plays an important role in the pathogenesis, progression and outcome of major human diseases. Chronic/persistent hypoxia triggers cancer progression, severe obesity and metabolic syndrome, diabetes complications, in addition to contributing to damages in neurodegenerative diseases, storage diseases, b-fibrillosis, cell hypertrophy, obstructive sleep apnea, microvessel diseases, fibrosis, and age-related diseases. Additionally, migraine, high-altitude adaptation and anemia are also conditioned by hypoxia.

It is of significance that this close relationship between hypoxia-dependent and inflammatory-reparative pathways be translated at the clinical level by identifying new (and common) diagnostic/prognostic biomarkers for stage evaluation and, importantly, for new therapeutic approaches and more precise molecular targets during the progression of the disease.

This Special Issue aims to systematically collect the available evidences of the crucial role of the hypoxia/inflammation axis in various human diseases. Your contributions should be focused in particular on: what the specific genesis of the hypoxic microenvironment is.; what molecular damage pathway(s) are activated; the identification of biomarkers for a more precise diagnosis, damage progression and a predictive prognosis; and suggesting new, non-canonical therapeutic strategies versus traditional therapeutics, even utilizing off-label drugs already available.

Prof. Dr. Matteo A. Russo
Dr. Marco Tafani
Guest Editors

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• molecular aspects of hypoxia and inflammation in cancer
• cancer progression as an integrated response to hypoxia adaptation and inflammation
• hypoxia and inflammation in cardiology
• hypertrophy, myocarditis, and heart failure
• hypoxia and inflammation in storage diseases (such as Fabry's disease)
• hypoxia and inflammation in infiltrative diseases (amyloidosis and other beta-fibrillosis)
• hypoxia and inflammation in obesity and type 2 diabetes complications
• hypoxia and inflammation in chronic inflammatory disease with progressive fibrosis
• HIF/NFkB in neurodegenerative diseases
• HIF/NFkB activation in other chronic hypoxic conditions