Advances in Neurodegenerative Diseases Research and Therapy—Third Edition

Dear Colleagues,

Degenerative diseases of the nervous system affect millions of people worldwide and have limited therapeutic interventions available presently since the blood–brain barrier restricts the passage of most drug candidates into the brain tissue. The term ‘neurodegenerative disease’ is often used as an umbrella term which includes various debilitating conditions which affect the brain, including Alzheimer’s, Parkinson’s, Huntington’s diseases, etc. Previous studies have focused on neuronal degeneration as the primary cause of these diseases, but recent evidence points towards the contribution of glial cells in maintaining a physiological and functioning neural output. Although these diseases have different pathological markers and clinical symptoms, they share common molecular pathways, including gliosis, proteostasis, inflammation, metabolic alterations, etc. It has been evident that understanding the molecular changes occurring during the development and progression of neurodegenerative diseases may lead to the development of effective therapeutic interventions.

This Special Issue, entitled ‘Advances in Neurodegenerative Diseases Research and Therapy—Third Edition’, continues to invite the submission of original research and review articles to provide the latest update on the molecular changes associated with neurodegenerative diseases. Special focus is also on the development of ‘clinically relevant’ therapeutic strategies against neurodegenerative diseases (including optimization studies, clinical efficacy studies, biomarker evaluation, drug delivery, etc.).

Dr. Sumonto Mitra
Guest Editor

Manuscript Submission Information

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• neurodegenerative diseases
• therapy
• molecular mechanisms
• neuron
• astrocytes
• microglia
• inflammation
• brain
• drug delivery

• Advances in Neurodegenerative Diseases Research and Therapy 2.0 in International Journal of Molecular Sciences (8 articles)