Molecular Insights into Lipodystrophy

Dear Colleagues,

Lipodystrophy syndromes refer to a group of rare disorders, characterized by a partial or almost-complete loss of adipose tissue. Some disease subtypes are associated with abnormal fat accumulation. These conditions, often stemming from genetic variants, disrupt metabolic balance, leading to complications such as insulin resistance, diabetes mellitus, and dyslipidemia. Individuals with lipodystrophy may exhibit distinct body fat patterns, ranging from localized depletion (lipoatrophy) to disproportionate accumulation (lipohypertrophy). Understanding the molecular basis of lipodystrophy syndromes is crucial for advancing diagnosis and developing targeted therapies to mitigate metabolic complications associated with these rare disorders.

Featuring studies on genetic variants, adipocyte biology, lipid metabolism, and insulin signaling pathways, this Special Issue aims to delve into the intricate molecular mechanisms underlying lipodystrophy syndromes in order to explore how these molecular factors contribute to metabolic complications such as diabetes, dyslipidemia, and hepatic steatosis, ultimately paving the way for innovative therapeutic interventions and improved patient outcomes.

Dr. Sofía Sánchez-Iglesias
Dr. David Araújo-Vilar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• lipodystrophy
• adipogenesis
• animal models
• lipid metabolism
• therapeutic targets
• insulin signaling pathways
• adipose tissue