Metabolomics in Oncology

Dear Colleagues,

Cancer cells reprogram their metabolism by consuming high levels of glucose and some nonessential amino acids (like glutamine, serine, and others), producing reactive oxygen species, and potentiating the synthesis of nucleotides, fatty acids, and lipids. The application of metabolomic profiling to biological fluids and matrices has recently emerged as a powerful and reliable tool for identifying novel biomarkers to improve early diagnosis and prognostication and for predicting the response of cancer patients to treatment. The large-scale study of metabolites in biological samples, such as cells, tissues, or biological fluids, takes advantage of several technologies, like 1H-nuclear magnetic resonance (1H-NMR) spectroscopy; gas chromatography–mass spectrometry (GC-MS), liquid chromatography–mass spectrometry (LC-MS), Fourier-transform infrared spectroscopy (FT-IR), and vibrational and Raman spectroscopy.

The aim of this Special Issue is to present the latest research and new studies based on metabolomics approaches applied to cancer research on different biological matrices such as cancer cells, tissues, and biological fluids. Pure clinical studies would not suitable for our Special Issue; however, clinical submissions with biomolecular/metabolomic experiments will be welcome.

Dr. Susan Costantini
Dr. Elena Di Gennaro
Guest Editors

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• metabolome
• cancer
• oncology
• nuclear magnetic resonance
• mass spectrometry