Molecular Mechanisms and Therapy of Cardiomyopathy

Dear Colleagues,

Cardiovascular disease is the leading cause of morbidity and mortality globally. Its prevalence necessitates a detailed understanding of the molecular mechanisms underlying cardiomyopathy to develop targeted therapeutic strategies. Several molecular aberrations have been described in cardiomyopathies of all etiologies, including changes in cardiac contractility and morphology, vascular/endothelial dysfunction, mitochondrial and metabolic dysfunction, ischemia/reduced oxygen perfusion, immune cell dysfunction, and epigenetic mechanisms. These molecular mechanisms have yielded several pharmacological treatment strategies for cardiomyopathies of all etiologies. In addition to pharmacological interventions, lifestyle modification (e.g., nutrition/exercise) is now recommended for patients with cardiomyopathy, and several studies have identified molecular changes from such interventions. Thus, investigating the complex molecular aspects of cardiomyopathies is fundamental for identifying the key signaling pathways, genetic and epigenetic factors, and cellular processes that drive disease progression. Improving our knowledge of the mechanistic basis of cardiomyopathies allows for generating novel therapeutic approaches with the goal of improving patient lives.

This Special Issue is supervised by Dr. Maicon Landim-Vieira, who is assisted by the Guest Editor's Assistant Editor Dr. Ann Centner (Florida State University).

Dr. Maicon Landim-Vieira
Guest Editor

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• cardiomyopathy
• nutrition
• exercise
• pharmacology
• molecular mechanisms