Molecular Advances in Periodontitis Diagnosis and Treatment

Dear Colleagues,

Periodontal and peri-implant tissues are mainly made up of type I collagen, and collagen breakdown is one of the main pathologic events in active periodontal degeneration, related to periodontitis and peri-implantitis destructive lesions. In addition to traditional clinical and radiological diagnostic measurements, the diagnosis of periodontal and peri-implant diseases can additionally be refined with immunological and microbiological tests, utilizing oral fluids or dental plaque. For example, The point of care tests (POCTs) are welcome and possible to be determined from the gingival crevicular fluid (GCF), peri-implant sulcus fluid (PISF), and other oral fluids such as mouth rinse and saliva. We can monitor important processes such as periodontal soft tissue inflammation, alveolar bone loss, etc., through various biomarkers such as matrix metalloproteinase, collagen telopeptidase, α2-macroglobulin, etc. We also wish to address the investigation of different adjunctive host-modulating periodontal therapies to support classical periodontal treatment (i.e., anti-infective treatment/scaling and root planing). The common host-modulation medications include antiproteinases, anti-inflammatories, subantimicrobial-dose doxycycline, etc. At present, modern and future diagnostics at a molecular level and host-modulating anti-infective therapies and means are needed for proper diagnosis, treatment, and plaque control in periodontitis and peri-implantitis. Utilizing these, one can prevent and cease the progression of periodontitis and peri-implantitis and support the maintenance of periodontal and peri-implant treatment outcomes and health.

This Special Issue is now soliciting papers on topics related to molecular-level diagnosis and periodontitis treatment.

Prof. Dr. Timo Sorsa
Guest Editor

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• periodontitis
• peri-implantitis
• point-of-care diagnostic
• molecular diagnostic
• metalloproteinase 8
• biomarkers
• host-modulation medication
• plaque control