Coenzyme Q in Health and Disease

Dear Colleagues,

Coenzyme Q is an essential endogenous lipophilic cofactor ubiquitous in biological membranes where it promotes cellular bioenergetics acting as an electron shuttle between complexes I, II and III of the mitochondrial respiratory chain. Its reduced form, ubiquinol, is considered the most powerful fat-soluble endogenous antioxidant, acting directly as a radical scavenger and indirectly regenerating other antioxidant molecules such as vitamin E and vitamin C. Recently, new evidences have highlighted its involvement also in the modulation of gene expression and in the regulation of mitochondrial transition pore and uncoupling proteins, with important implications in the senescence process. In light of its biological role, CoQ10 supplementation could represent a relevant strategy to compensate for its deficit not only associated with a primary deficiency, due to mutations in the genes involved in its biosynthesis, but also in both physiological conditions including ageing, physical activity, pharmacotherapy and pathological ones such as cardiovascular, metabolic and neurodegenerative diseases.

“Coenzyme Q in Health and Disease” aims to collect original articles as well as review articles that share information on the role of Coenzyme Q in the healthy and pathological subjects in relation to following (but not limited) areas: cardiovascular, metabolic, neurodegenerative disorders, fertility, sarcopenia, aging, physical activity, etc.

Dr. Patrick Orlando
Dr. Fabio Marcheggiani
Guest Editors

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• CoQ deficiency
• aging
• physical exercise
• CoQ bioavailability
• CoQ biosynthesis
• neurodegenerative disease
• fertility
• cardiovascular disease
• mitochondrial dysfunction
• inflammation
• sarcopenia
• mitochondrial dynamics