Cellular Oxygen Homeostasis 3.0

Dear Colleagues,

Oxygen facilitates the effective production of the cellular energy currency ATP. Cells sense and respond to the partial pressure of oxygen in their environment using a cell-type-specific toolkit of oxygen-sensitive ion channels, receptors, second messengers, transcription factors, and other enzymes. Cellular oxygen homeostasis is a prerequisite for proper cellular function and survival, and both an under-supply and excess of oxygen induce oxidative stress. Dysregulation induces the increased formation of reactive oxygen species, which override the redox buffering capability and modify lipids and proteins. The changes in enzymatic activity can affect all aspects of cellular function, including metabolism, development, differentiation, cellular secretions, epigenetic mechanisms, and gene expression. A good insight into these molecular mechanisms is a prerequisite to understand processes such as aging and diseases such as stroke, ischemia, malignant transformations, and metastasis to finally develop new pharmacological treatments. We invite interested investigators in this field to contribute original articles or reviews to this Special Issue with a focus on molecular mechanisms of cellular responses to different oxygen conditions, whether it be with the help of in vitro models, animal models, or in humans, which might provide insight into clinically relevant questions.

Dr. Verena Tretter
Guest Editor

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• cellular oxygen homeostasis
• redox signaling
• cellular oxygen sensing
• hypoxia
• hyperoxia