Therapeutic Strategies to Target Cancer Neoantigens
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 97
Special Issue Editor
Special Issue Information
Dear Colleagues,
The success of cancer immunotherapy relies on a patient T-cells-recognizing antigens derived from tumor-specific mutations, which then attack the antigen-presenting cell. Accumulating evidence suggests that clinically efficacious cancer immunotherapies are driven by T-cell reactivity against DNA mutation-derived neoantigens. However, among the large number of predicted neoantigens, only a minority are recognized by autologous patient T cells, and strategies to broaden neoantigen-specific T-cell responses are therefore attractive. We propose to summarize current and emerging strategies to improve neoantigen presentation, identification and targeting.
Prof. Dr. James J. Driscoll
Guest Editor
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Keywords
- cancer immunotherapy
- antigen
- neoantigen
- T-cells
