Chromatin Remodelers as Players and Drivers in Pathological States

Dear Colleagues,

I would like to draw our attention to chromatin remodelers, particularly their role and contribution to the development of pathological states, such as cancer.

Indeed, it is known that proteins such as INO80, CHD7, or RSF1 participate in the regulation of oncogenes at different levels, mainly through the recruitment of other mediators and, therefore, their overexpression in different human tissues. On the other hand, some of them are considered tumor suppressors, such as HLTF or ZRANB3, since they bypass DNA damage or stimulate damage repair. Of note, SMARCAL1 from the same SNF2 family was recently characterized as a dual agent in cancer cells, underscoring its multipurpose and critical involvement in maintaining genome stability and regulating the cell cycle.

While this information goes a long way toward understanding how these proteins are regulated or actively regulate disease processes, there is still much to discover. The lack of sufficient structural and functional data and information at the cellular level impedes our understanding of their mechanistic effects on the development of this pathology.

This Special Issue aims to broaden current knowledge on this topic and constitutes an opportunity to gather the latest results obtained by experts in the field, which could potentially aid the design of new diagnostic and therapeutic tools.

Dr. Matteo De March
Guest Editor

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• protein structure/function
• chromatin remodelers
• DNA repair
• oncogene/oncosuppressor
• cancer