Signaling Pathways and Novel Therapies in Heart Disease

Dear Colleagues,

Heart disease continues to be a leading cause of morbidity and mortality worldwide, necessitating ongoing research efforts to identify novel therapeutic approaches. This Special Issue will explore the intricate signaling pathways involved in cardiac pathogenesis and showcase innovative therapies, including gene therapy and pharmacotherapy. By delving into the molecular mechanisms underlying cardiac dysfunction and highlighting promising treatment modalities, this Special Issue will advance the collective understanding and management of heart disease.

Topics of interest include, but are not limited to, the following:

• Identification and characterization of signaling pathways implicated in heart disease;
• Role of signaling pathways (e.g., MAPK, PI3K/Akt, Wnt/β-catenin, mTOR) in heart disease;
• Molecular mechanisms underlying cardiac hypertrophy, fibrosis, and remodeling;
• Role of inflammation and immune signaling in cardiovascular disorders;
• Novel therapeutic targets for heart failure, arrhythmias, and ischemic heart disease;
• Precision medicine approaches in the treatment of cardiac arrhythmias;
• Therapeutic modulation of autophagy and apoptosis in ischemic heart disease;
• Emerging gene- and cell-based therapies for myocardial regeneration;
• Application of nanomedicine and drug delivery systems in cardiac therapeutics;
• Clinical trials and translational research in cardiovascular pharmacotherapy;
• Challenges and opportunities in drug discovery and the development of advanced treatment strategies for heart disease;
• Advances in gene therapy for inherited cardiac disorders and acquired heart diseases;
• Pharmacological interventions targeting key signaling molecules and pathways in heart disease;
• Development of targeted therapies and precision medicine approaches for the personalized treatment of heart disease.

We invite researchers, clinicians, and scientists from diverse disciplines to contribute original research articles, reviews, and perspectives discussing the signaling pathways and therapeutic strategies shaping the future of cardiovascular medicine. Together, we can translate cutting-edge research into effective treatments that improve outcomes for patients with heart disease.

Dr. Anindita Das
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• heart failure
• arrhythmias
• ischemic heart disease
• myocardial regeneration
• inflammation
• gene- or cell-based therapy
• precision medicine