Psoriasis: Molecular Research and Novel Therapy

Dear Colleagues,

Psoriasis has pioneered advances in the use of biologics for its treatment for more than a decade in dermatology due to the better understanding of its pathogenesis. Biologics have become the gold standard in the treatment of moderate to severe psoriasis. However, there is also a recent trend for the use of novel oral agents, starting from apremilast and deucravacitinib to oral peptides targeting IL23 receptors and others.

The dichotomy of psoriasis and atopic dermatitis based on yin-yang theory has been replaced by more sophisticated immunologic mechanisms in recent years. Not only are immune cells involved but also other cells such as keratinocytes, fibroblasts, mast cells, and endothelial cells. Also, the discovery of IL36 receptor antagonist deficiency as the core cause of pustular psoriasis helps in our understanding of the many facets of psoriasis and its treatment.

For the treatment of psoriasis, which is a chronic disease in most cases, the potentials for better long-term control and even disease modification after treatment discontinuation have also come into the spotlight.

In this Special Issue of IJMS, submissions on “Psoriasis: Molecular Research and Novel Therapy" are welcome.

Prof. Dr. Tsen-Fang Tsai
Guest Editor

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• psoriasis
• pathogenesis
• treatment
• biologics
• novel therapy