Bone Marrow Concentrate: New Molecular Research

Dear Colleagues,

Bone Marrow Aspirate Concentrate (BMAC) therapies have been employed for more than 30 years to treat pathologies across a multitude of medical fields. The use of autologous BMAC biological formulations has resulted in considerable interest and discussions. The focus of published BMAC original articles and narrative reviews was on the biological function of bone marrow mesenchymal and progenitor stem cells, various platelet-derived growth factors, and leukocytes, including their mode of action, and the effect of BMAC during the various stages of tissue repair, regeneration, and wound healing, in a variety of pathological conditions.

A better understanding of the molecular function of the bone marrow niches, cell signaling processes, and the biological effects of BMACs must be further refined and should translate to improved clinical outcomes as well as an expansion in the growth of clinical indications. Ideally, new insights should become available regarding dosing strategies, inflammation, immunomodulation, angiogenesis, and painkilling effects in order to improve patient outcomes and address molecular mechanisms to promote tissue healing and repair. Consequently, increased understanding of BMAC biological interactions, and combination with other biological preparations like platelet-rich plasma and adipose tissue formulations, presents a challenge in identifying the critical mechanisms behind effective non-surgical treatments for BMAC.

This Special Issue welcomes and encourages the submission of research articles and full reviews providing insight and information on the latest developments in BMAC molecular research, patient outcomes for musculoskeletal and spine diseases, as well as new applications of BMAC such as in fertility diseases, neuroinflammation, and degenerative diseases.

Dr. Peter Everts
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• bone marrow aspirate concentrate
• mesechymal stem cell
• tissue repair
• tissue regeneration
• wound healing
• anti-inflammatory
• immunomodulation
• angiogenesis
• degenerative disease