Molecular Insights into Metabolic Pathways and Age-Related Pathologies

Dear Colleagues,

The World Health Organization defines a person as elderly when she/he is 65 years of age or above. In 2020, more than 147 million people worldwide were between the ages of 80 and 99, accounting for 1.9% of the world's population. The increased life expectancy in industrialized countries has unfortunately also led to a significant increase in the incidence of age-related diseases (ARDs), including cardiovascular diseases, cancer and neurodegenerative disorders. Senescent cells are characterized by the presence of specific phenotype known as senescence-associated secretory phenotype (SASP) due to synthesis and release of matrix-degrading molecules and pro-inflammatory mediators. SASP contributes to the establishment and maintenance of low-grade inflammation (“inflammaging”) which promotes the major ASDs inducing changes in the metabolic pathways responsible for cellular homeostasis. Intensive research activity defined several hallmarks of aging including genomic instability, telomere shortening, epigenetic alterations, loss of proteostasis, deregulating nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication. In this Special Issue, we invite authors to submit original research and review articles investigating different metabolic changes leading to ASDs and associated therapeutic approaches. Also, we gratefully appreciate all the contributions focused on the identifications of novel biomarkers useful for the diagnosis and prognosis of ARDs.

Dr. Arianna Vignini
Dr. Monia Cecati
Guest Editors

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• aging
• age-associated diseases
• dysregulated metabolic pathways
• inflammation
• biomarkers
• therapeutics