Molecular Targeted Therapy for Gliomas

Dear Colleagues,

The molecular signature of gliomas is now an integral part of the World Health Organisation (WHO) classification system of brain tumours, which provides powerful prognostic information. Despite advances in molecular targeting and innovative treatment approaches, tumour heterogeneity continues to pose daunting challenges, with individual tumours containing a spectrum of cellular subtypes which are able to transit between different cellular states. Combination treatment targeting different cellular vulnerabilities may serve as a promising approach to overcome tumour heterogeneity. However, the development of rational and effective therapeutic regimens is still impeded by inadequate insights into the mechanisms that govern glioma plasticity.

Supervised by Prof. Dr. Gilberto Ka-Kit Leung and assisted by our Topical Advisory Panel Member Dr. Karrie Mei Yee Kiang from The University of Hong Kong, this Special Issue “Molecular Targeted Therapy for Gliomas” of the International Journal of Molecular Sciences aims to introduce novel findings on glioma tumour biology in areas such as the identification of molecular targets; innovative tools or techniques on molecular profiling; and targeting approaches that would enhance treatment efficacy, overcome chemoresistance, and promote drug delivery, with a view to explore new avenues for glioma treatment.

Prof. Dr. Ka-Kit Leung
Guest Editor

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• targeted therapy
• glioma and glioblastoma
• treatment strategies
• identification of biomarkers
• diagnosis
• prognosis
• molecular pathology
• signalling pathways
• molecular imaging
• tumour microenvironment