Molecular Relationships between Brain and Lung Diseases

Dear Colleagues,

The brain has numerous connections with several organs and systems. Recent advances have shown the existence of a functional and bidirectional crosstalk between the brain and lungs, which is formed probably due to the presence immune, neuronal, anatomic, and endocrine pathways.

Specifically, the brain regulates the lungs via the neuroanatomical, humoral, immune, and metabolic pathways. Lungs too influence the brain primarily through the humoral, immune, pathogenic microorganisms and metabolic pathways. Because of this interconnection, certain diseases may occur simultaneously in both these systems, or a disease in one of the systems may cause a disease in the other.

Moreover, it is reasonable to hypothesize that there is a involvement of certain parts of the brain in the pathogenesis of lung disease. In light of their pleiotropic role, we strongly believe that further studies are urgently required to investigate the role of potential biomarkers that can specifically reflect the development, occurrence, and progression of the neurologic and pulmonary pathological conditions.

This Special Issue aims to provide an updated overview of the major disorders in the interface between neurology and pulmonology and include interdisciplinary analyses using conceptual research approaches based on physiology and pathophysiology, particularly with a focus on molecular physiology, that can map out the prospects for the lung–brain axis.

We invite authors to submit both original papers and review articles.

This Special Issue is supervised by Dr. Sara Manti and assisted by our Topical Advisory Panel Member Dr. Antonio Nicotera, Dr. Salvatore Leonardi and Dr. Gabriella Di Rosa.

Dr. Sara Manti
Guest Editor

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• newborns
• children
• lung diseases
• neurodevelopmental disorders