Molecular Research on Neurodegenerative Diseases 4.0

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issues "Molecular Research on Neurodegenerative Diseases", "Molecular Research on Neurodegenerative Diseases 2.0" and "Molecular Research on Neurodegenerative Diseases 3.0".

Many neurological disorders are characterized by neurodegenerative processes, with key molecular signaling pathways participating in cascades of cell death events. Even brain diseases traditionally considered as acute central nervous system injuries, such as stroke and traumatic brain injury, have now been recognized as presenting major pathological components, known as hallmarks of chronic neurodegeneration. Among the many molecular signatures of neurodegeneration, specific molecules associated with inflammation and mitochondrial dysfunction have been implicated as pivotal checkpoints in the propagation of cell death mechanisms, yet have also been shown to be equally involved as robust targets for anchoring cell survival therapeutics. This Special Issue is dedicated to the recent research progress made in deciphering the molecular pathways mediating cell death and cell survival in neurodegeneration and its treatment. Our goal is to provide an in-depth understanding of the underlying central role of neurodegeneration in brain diseases and to exploit such knowledge for the development of novel molecule-based therapies against neurodegenerative disorders.

Prof. Dr. Cesar Borlongan
Guest Editor

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• neurological disorders
• stroke
• traumatic brain injury
• neurodegeneration
• Parkinson's disease
• molecular pathways

• Molecular Research on Neurodegenerative Diseases 3.0 in International Journal of Molecular Sciences (22 articles)