Molecular Mechanisms Underlying Pancreatic Cancer Progression and Drug Resistance

Dear Colleagues,

Pancreatic ductal adenocarcinoma (PDAC) poses a formidable challenge in oncology due to its high mortality rate, stemming from late detection, rapid metastasis, and resistance to conventional therapies. This Special Issue aims to explore the intricate molecular pathways driving PDAC progression and treatment resistance. Our focus spans various topics, including genetic and epigenetic alterations in tumor initiation and progression, the influence of the tumor microenvironment on cancer aggressiveness, and the molecular mechanisms behind resistance to chemotherapy, immunotherapy, and emerging novel targeted therapies. This issue will also highlight cutting-edge technologies and methodologies such as single-cell sequencing, spatial transcriptomics, and 3D patient tumor avatars (3D-PTAs), which enhance our understanding of PDAC progression and therapeutic resistance. We encourage contributions of original research articles, reviews, and perspectives that illuminate these critical areas to advance our understanding and pave the way for more effective interventions to improve PDAC patient outcomes.

Dr. Daoyan Wei
Prof. Dr. Robert S. Bresalier
Guest Editors

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• pancreatic cancer
• cancer progression
• therapeutic resistance
• targeted therapies
• oncogenic pathways
• molecular pathogenesis
• tumor heterogeneity
• tumor microenvironment
• precision oncology