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Molecular Mechanisms of Oral and Gastrointestinal Bacterial Interaction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (25 September 2024) | Viewed by 1285

Special Issue Editor


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Guest Editor
1. Microbial Interactions Laboratory, Faculty of Dentistry, Universidad Andrés Bello, Santiago 8370133, Chile
2. Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile
Interests: oral and gastrointestinal bacterial interaction; control mechanisms of oral bacteria; oral cancer; nanoparticles

Special Issue Information

Dear Colleagues,

The molecular mechanisms of oral and gastrointestinal bacterial interaction are crucial in comprehending the intricate relationship between these microbial communities and their impact on human health. Research in this field has unveiled a dynamic interplay between the oral and gastrointestinal microbiota, influencing various disease processes and systemic conditions. Key pathogenic mechanisms, such as biofilm formation, bacterial adhesion, microbial metabolites, and host immune responses, play pivotal roles in shaping these interactions. Advances in molecular biology techniques have enabled the identification of specific bacterial strains, virulence factors, and signaling pathways involved in these complex interactions. Unraveling these mechanisms offers insights into the pathogenesis of oral and gastrointestinal diseases, paving the way for targeted therapeutic strategies and precision medicine approaches to modulate the microbiome in order to improve health outcomes.

The proposed topics for this Special Issue include:

  1. Host immune responses to oral and gastrointestinal microbiota;
  2. Biofilm formation and antibiotic resistance in oral and gastrointestinal bacteria;
  3. Impact of diet on oral and gastrointestinal microbiota composition;
  4. Dysbiosis in the oral gastrointestinal microbiome: investigating the impact on systemic health;
  5. Metagenomic analysis of oral and gastrointestinal microbiota.

This Special Issue welcomes the submission of original research articles and reviews related to oral and gastrointestinal bacterial interaction. Mini-reviews and reviews are also welcome to be submitted.

Dr. Denisse Bravo
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • oral and gastrointestinal microbiota
  • bacterial interaction
  • pathogenic mechanisms
  • immune responses
  • biofilm formation
  • bacterial adhesion
  • microbial metabolites

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Published Papers (1 paper)

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Research

13 pages, 3259 KiB  
Article
The Association between Salivary Metabolites and Gingival Bleeding Score in Healthy Subjects: A Pilot Study
by Rita Antonelli, Elena Ferrari, Mariana Gallo, Tecla Ciociola, Elena Calciolari, Alberto Spisni, Marco Meleti and Thelma A. Pertinhez
Int. J. Mol. Sci. 2024, 25(10), 5448; https://doi.org/10.3390/ijms25105448 - 17 May 2024
Viewed by 984
Abstract
Periodontal diseases, including gingivitis and periodontitis, are among the most prevalent diseases in humans. Gingivitis is the mildest form of periodontal disease, characterized by inflammation of the gingiva caused by the accumulation of dental plaque. Salivary diagnostics are becoming increasingly popular due to [...] Read more.
Periodontal diseases, including gingivitis and periodontitis, are among the most prevalent diseases in humans. Gingivitis is the mildest form of periodontal disease, characterized by inflammation of the gingiva caused by the accumulation of dental plaque. Salivary diagnostics are becoming increasingly popular due to the variation in saliva composition in response to pathological processes. We used a metabolomics approach to investigate whether a specific saliva metabolic composition could indicate preclinical stage of gingivitis. 1H-NMR spectroscopy was used to obtain the salivary metabolite profiles of 20 healthy subjects. Univariate/multivariate statistical analysis evaluated the whole saliva metabolite composition, and the Full-Mouth Bleeding Score (FMBS) was employed as a classification parameter. Identifying a signature of specific salivary metabolites could distinguish the subjects with high FMBS scores but still within the normal range. This set of metabolites may be due to the enzymatic activities of oral bacteria and be associated with the early stages of gingival inflammation. Although this analysis is to be considered exploratory, it seems feasible to establish an FMBS threshold that distinguishes between the absence and presence of early inflammatory alterations at the salivary level. Full article
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