Targeting Tumor Angiogenesis: Challenges and Opportunities

Dear Colleagues,

Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. However, it is also a fundamental step in the transition of tumors from a benign state to a malignant one; exacerbated angiogenesis confers advantages to tumor growth and metastasis. Understanding the molecular mechanism of angiogenesis is not only the basis for analyzing tumor progression, but also an important target for human tumor therapy. The formation of the vascular system occurs through the coordination of multiple cell types and signaling networks. Chemical stimulation is the main cause of angiogenesis. Many transcription factors govern the expression of metabolic proteins, adhesion molecules, matrix components, and growth factors. Several transcription factors have been identified as angiogenic process drivers, including HIF-1, NF-kB, AP-1, the SOX family, PROX1, SP-1, and other endothelial and/or tumor transcription factors. Meanwhile, changes in the intracellular environment can also trigger angiogenic growth buttons. This Special Issue aims to collect cutting-edge research on angiogenesis, research on the development of drugs that inhibit angiogenesis as therapeutic targets, and studies on the molecular pathways that modulate angiogenesis. Original research papers and review articles on these different areas are welcome.

Prof. Dr. Anca Maria Cimpean
Guest Editor

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• tumor angiogenesis
• lymphangiogenesis
• transcription factors
• growth factors
• targeted therapy
• gene therapy