Exposome and Mechanisms of Brain Pathology: From Single Cell to Cerebral Networks and Behavior

Dear Colleagues,

Introduced by Wild in 2005, the “exposome” concept describes the internal and external exposures across life-course that affect human health. Exposure to multiple environmental factors, including diet, toxins, physical or psychological stress, social adversity, air pollution, sleep deprivation and/or jet lag, etc. exhibits a dynamic impact on brain structure and function resulting in a wide range of brain alterations that can be transient or chronic while they may alter vulnerability to brain pathology. This Special Issue aims to explore recent advances on the underlying neurobiological mechanisms of external and/or internal exposures from the cellular level to cerebral circuits and behavior, addressing mechanistic insights of different neural exposomes in cellular and animal models, organoids, as well as humans.

We invite researchers to contribute review articles and original high-quality research on the impact of the “exposome”, as risk or/and protective factors on the molecular, cellular, genetic, epigenetic, metabolic and connectomic profile of the brain and its related behavioral output.

The subtopics to be covered within this collection are listed below, including but not limited to:

-Impact of external exposure, including:

• Diet;
• Neurotoxic agents;
• Acute or chronic stress;
• Social adversity;
• Air pollution;
• Sleep deprivation and/or jet lag, etc.

- Impact of the internal environment, such as:

• Metabolism;
• Hormones;
• Inflammation;
• Oxidative stress.

Dr. Catherine R. Dermon
Dr. Ioannis Sotiropoulos
Dr. Joana Silva-Correia
Guest Editors

Manuscript Submission Information

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• neural exposomes
• brain pathology
• epigenetic of brain
• neurobiological mechanisms