Exploring the Complex Interplay between Metabolic Diseases, MASLD, and Liver Cancer

Dear Colleagues,

This Special Issue aims to collect research devoted to unraveling the molecular mechanisms underlying the intricate relationship between metabolic dysfunction-associated fatty liver disease (MASLD), metabolic disorders, and liver cancer, mainly hepatocellular carcinoma (HCC). MASLD has emerged as a critical precursor of more severe liver conditions, including metabolic dysfunction-associated steatohepatitis (MASH) and HCC. The interplay between MASLD and metabolic disorders, such as obesity, insulin resistance, and dyslipidemia, significantly exacerbates the risk of HCC development.

This Special Issue aims to expand the comprehension of the roles of metabolic dysfunction, chronic inflammation, oxidative stress, and genetic predispositions in the onset of MASLD and in triggering hepatic carcinogenesis. Additionally, the impact of dietary habits and environmental exposures on disease progression will be thoroughly examined.

Moreover, this Special Issue seeks to include studies investigating the molecular mechanisms that may be involved in the progression of MASLD to MASH and liver cancer and suggesting novel biomarkers for the early detection, risk stratification, and personalized intervention strategies for MASLD patients with metabolic comorbidities to mitigate HCC risk. Furthermore, comprehensive reviews, original research articles, and expert perspectives on studies on novel diagnostic biomarkers and therapeutic targets to enhance disease surveillance and management are also welcomed.

Dr. Daniela Gabbia
Dr. Sara De Martin
Guest Editors

Manuscript Submission Information

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• hepatocellular carcinoma
• MASLD
• MASH
• obesity
• insulin resistance
• dyslipidemia
• liver cancer