Oxidative Stress and Mitochondrial Dysfunction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1289
Special Issue Editor
Interests: mitochondrial dysfunction; traumatic brain injury, oxidative/nitrosative stress; energy metabolism; neurodegenerations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Acute (e.g., stroke, traumatic brain injury, etc.) and chronic (e.g., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, etc.) neurodegenerations are characterized by two profound differences. For the former, the onset of symptoms coincides with the onset of the pathology, with the originating causes, therefore, being known, whilst for the latter, the onset of symptoms is delayed for an unknown period of time with respect to the actual onset of the pathology, with the triggering causes being unknown (or, at the minimum, controversial). Notwithstanding, at the molecular level, acute and chronic neurodegenerations share a number of common pathobiological mechanisms, including oxidative/nitrosative stress, energy penalty, mitochondrial malfunctioning, changes in gene and protein expressions, neuroinflammation, etc. In a large number of cases, the severity of these biochemical/metabolic/molecular alterations is linked to patient outcome (in the case of acute neurodegenerations) and to the progression of the disease (in the case of chronic neurodegenerations).
The aim of this Special Issue is to compile original contributions concerning the interconnections present among the aforementioned pathobiological mechanisms, with special attention paid to oxidative/nitrosative stress and mitochondrial dysfunction in any experimental or clinical model of acute and chronic neurodegenerations. Review article are also welcome, especially if finalized to evaluate the state-of-the-art of potential novel pharmacological approaches.
Prof. Dr. Giuseppe Lazzarino
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative/nitrosative stress
- mitochondrial dysfunction
- gene and protein expressions
- neuroinflammation
- stroke
- traumatic brain injury
- Alzheimer’s disease
- Parkinson’s disease
- amyotrophic lateral sclerosis
- multiple sclerosis
- acute and chronic neurodegenerations
