Exosomes in Health and Diseases

Dear Colleagues,

Exosomes, small extracellular vesicles originating from endosomal compartments, have emerged as key mediators of intercellular communication, playing pivotal roles in both health and disease. These nanosized vesicles carry a diverse cargo of proteins, nucleic acids, and lipids, reflecting their cellular origin. In health, exosomes contribute to various physiological processes, such as immune regulation, tissue repair, and neuronal communication. Conversely, the dysregulation of exosome release and content has been implicated in the pathogenesis of numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Additionally, in cardiovascular diseases, exosomes influence vascular remodeling and inflammation, contributing to disease progression. Understanding the dual role of exosomes in health and disease presents exciting opportunities for diagnostic and therapeutic advancements. Exosomes hold promise as biomarkers for early disease detection and monitoring due to their presence in various biological fluids. Moreover, their natural ability to deliver cargo to specific target cells suggests their potential as therapeutic vehicles for targeted drug delivery.

In this Special Issue, we aim to shed new light on the current advances in exosomes. We cordially invite researchers working in these areas to contribute to this Special Issue with original research or reviews.

Dr. James Grant Nicholas
Guest Editor

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• exosomes
• intercellular communication
• immune regulation
• tissue repair
• neuronal communication
• drug delivery