Anemia and Iron Metabolism: Laboratory Diagnosis, Novel Biomarkers and Environmental Influence

Dear Colleagues,

Anemia is one of the most common signs found in clinical practice. In a vast majority of the cases, anemia is not caused by a hematology specific disorder, but is secondary to diverse systemic diseases, including the anemia of chronic diseases. Anemia related to specific hematology disorders can be acquired or congenital.

Normal iron metabolism is crucial for the development of the hemoglobin molecule and as a result, any disorder that affects this metabolism can be linked to the etiology of anemia, in chronic systemic diseases and in congenital or acquired diseases. Iron metabolism abnormalities can cause iron deficiency or iron overload. The molecules that are known to be crucial in maintaining normal iron metabolism are ferroportin and hemojuvelin that control iron absorption, transferrin, iron transporters, soluble transferrin receptors that allow iron incorporation into the cells, ferritin, the main molecule that allows iron storage, hepcidin, a regulator of iron availability and erythroferrone that regulate hepcidin activity. The focus of this Special Issue is research regarding the activity of all those molecules and others that can be the goal of future research. We will welcome laboratory and basic research studies, or reviews that provide significant new information on the pathophysiology of anemia and iron metabolism and possible future treatment approaches.

Prof. Dr. Ariel Koren
Dr. Carina Levin
Guest Editors

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• anemia
• iron metabolism
• anemia of chronic diseases
• iron deficiency
• congenital anemias
• hemoglobinopathies
• iron overload