The Relevance of Lipid Metabolism in Viral Hepatitis and Hepatocellular Carcinoma

Dear Colleagues,

Unexpected progress has been achieved in recent years with the approval of novel medications for the treatment of hepatocellular carcinoma (HCC). Yet, the enthusiasm around the availability of new compounds is not coupled with a significant improvement in the survival of respective patients. Viral hepatitis, a major cause of HCC worldwide, is resource-dependently adequately addressed; however, even after the sufficient suppression or even eradication of the viral infection, the emergence of HCC is still possible. Both underlying mechanistic interactions as well as efficient biomarkers are lacking in order to properly tailor early diagnosis and effective treatment. In the last two decades, lipid compounds have been under the spotlight since both viral hepatitis as well as HCC seem to interact with the abundant hepatic lipid microenvironment and thus regulate liver inflammation, fibrosis and carcinogenesis.

In this Special Issue, we aim to attract original papers and reviews offering novel insights into the significance of lipid metabolism in viral hepatitis and HCC, providing an interesting discussion.

Dr. Georgios Grammatikos
Guest Editor

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• sphingolipid
• ceramide
• HCC
• viral hepatitis
• sphingomyelinase
• exosomes
• immune therapy