Molecular Advances in Gastric Cancer

Dear Colleagues,

Stomach cancer is a very common cancer, ranking 5th in incidence and 4th in mortality worldwide. Research on the diagnosis and treatment of stomach cancer can greatly contribute to improving human health and life span. Environmental factors such as a high-salt diet and the presence of Helicobacter pylori have been studied extensively in the development of stomach cancer. It has been reported that TCGA-based molecular classification of gastric cancer is also related to prognosis. Molecular biomarkers can be used not only to understand the pathogenesis of gastric cancer, but also to diagnose the illness, predict prognosis, and predict treatment response. Molecular-based treatment is paving the way for precision medicine and personalized treatment. Aside from classic sequencing such as mRNA sequencing, miRNA sequencing, genomic sequencing, and 16S rRNA sequencing, advanced segueing methods such as single-cell sequencing and spatial sequencing can be used to obtain more precise information, accelerating the path to personalized treatment. Recently, primary organoid-based research with high similarity to in vivo study has been usefully used in research on carcinogenicity and the prediction of treatment response.

We therefore invite academic investigators working in all these fields to submit original research articles and reviews describing and discussing ‘molecular advances in gastric cancer.’

Potential topics include, but are not limited to:

• Outcome of gastric cancer treatment: molecular biomarker;
• New therapeutic issues in gastric cancer such as immunotherapy;
• Pathophysiology of gastric cancer;
• Sex difference in attributing molecular factors on gastric cancer;
• Effector modification by Helicobacter in the association between gastric cancer and other risk factors;
• The role of lipid and obesity in gastric cancer;
• Classic sequencing such as mRNA sequencing, miRNA sequencing, genomic sequencing, and 16S rRNA sequencing;
• Advanced methodology such as single-cell sequencing, spatial sequencing;
• Primary gastric cancer organoid-based study.

Dr. Su-youn Nam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• gastric cancer
• molecular biomarker
• sequencing
• organoid
• metabolic marker