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Cellular Senescence and the Senescence-Associated Secretory Phenotype (SASP) in Age-Related Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 54

Special Issue Editor


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Guest Editor
Department of Biochemistry and Physiology, Physiology Section, School of Pharmacy and Food Sciences, Universitat de Barcelona, 08028 Barcelona, Spain
Interests: pathophysiology; inflammation; cell biology; toxicology; neurodegeneration; COPD
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Special Issue Information

Dear Colleagues,

Cellular senescence, a state of irreversible cell cycle arrest, plays a crucial role in the pathogenesis of various age-related diseases. The senescence-associated secretory phenotype (SASP), a collection of pro-inflammatory cytokines, chemokines, and matrix-remodeling proteins, is a key mediator of the detrimental effects of senescent cells.

This Special Issue aims to explore the mechanisms by which cellular senescence and SASPs contribute to the development and progression of age-related diseases, such as atherosclerosis, chronic obstructive pulmonary disease (COPD), Alzheimer’s disease (AD), osteoarthritis (OA), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and cancer, among others.

This Special Issue seeks to bridge the gaps between cellular aging mechanisms and clinical manifestations, fostering advancements in diagnosis, treatment, and prevention strategies. Contributions from leading researchers will explore molecular pathways, identify biomarkers, and propose therapeutic targets, offering new insights into the complex interplay between aging cells and disease progression. We invite submissions of original research articles, reviews, and perspectives that investigate the role of senescence and SASPs in these diseases, as well as potential therapeutic interventions targeting senescent cells and their secretory phenotype.

Understanding the complex interplay between cellular senescence, SASPs, and age-related diseases will be crucial for developing novel strategies in order to promote healthier aging.

Dr. Jordi Olloquequi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular senescence
  • senescence-associated secretory phenotype (SASP)
  • age-related diseases
  • atherosclerosis
  • chronic obstructive pulmonary disease (COPD)
  • type 2 diabetes mellitus (T2DM)
  • non-alcoholic fatty liver disease (NAFLD)
  • Alzheimer’s disease (AD)
  • inflammation
  • therapeutic targets

Published Papers

This special issue is now open for submission.
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