New Insights into Coronary Vascular Pathophysiology: Gateways to Improved Therapies?

Dear Colleagues,

The past 5 years have seen a substantial acceleration of new understanding of the physiology and pathophysiology of human coronary circulation. It is now clear that microcirculation disorders are far more important than previously supposed and that coronary physiology varies substantially between young and old and between men and women. Neither acute nor chronic myocardial ischaemia reflects exclusively atheromatous large coronary obstruction, and thrombosis within the coronary circulation need not reflect plaque rupture.

These new pathophysiological findings all have substantial corollaries at the level of emerging therapeutic options, although in many cases, the clinical incorporation of these options is in its very infancy.

The Special Issue will focus primarily on an update of pathophysiologic progress in its many aspects, with a subsequent discussion of the changes in therapeutics of coronary disease, which are expected to occur as a consequence of this pathophysiological progress.

There will be 3 sections of articles:

1. Summaries of new pathophysiological insights within the coronary circulation;
2. Specific focus on the roles of these insights in various forms of acute and chronic ischaemic heart disease;
3. Focus on translational articles related to therapeutic initiatives dependent on a new understanding of pathophysiology.

Prof. Dr. John D. Horowitz
Guest Editor

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• coronary artery disease
• coronary microcirculation
• myocardial ischaemia
• heart disease in women
• cardiovascular ageing
• COVID-19 and coronary circulation