Recent Advances in Pathophysiology and Immunology Related to SARS-CoV-2 Infection

Dear Colleagues,

It has been three years since the worldwide spread of COVID-19, an extremely severe pandemic caused by a newly identified virus, termed SARS-CoV-2, a highly contagious betacoronavirus. The clinical spectrum of COVID-19 is extremely heterogeneous, ranging from an asymptomatic course to a very severe clinical scenario, with respiratory failure and death.

From a pathophysiological perspective, the chain of events from the first viral contact to the clinical manifestation, although known, may be unpredictable from one subject to another. In addition, the resolution phase of COVID-19 is not homogenous amongst patients. Whilst innate as well as adaptive immunity are crucial to combat infection, an excessive and dysregulated immune response is recognized to be counter-productive.

To enhance our comprehension of the pathophysiology and immunology of COVID-19, this Special Issue aims to collect the most recent evidence and advances in this specific field. Original research articles and comprehensive reviews covering the pathophysiological and immunological biomolecular aspects of SARS-CoV-2 infection and its clinical manifestations are welcomed in this Special Issue.

Dr. Vito D’Agnano
Guest Editor

Manuscript Submission Information

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• SARS-CoV-2
• COVID-19
• immunology
• pathophysiology
• immunopathology