The Role of Hormonal Receptors in Cancer: Molecular Mechanisms and Targeted Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 28
Special Issue Editor
Interests: GHRH; epithelial–mesenchymal transition; prostate cancer; breast cancer; tumor progression; exosomes; angiogenesis; antagonists; cell adhesion; cell proliferation
Special Issue Information
Dear Colleagues,
Understanding the role of hormonal receptors in cancer is paramount for developing effective treatment strategies. Hormonal receptors, such as estrogen and progesterone receptors in breast cancer, play crucial roles in tumor growth and progression. They orchestrate gene expression, fostering cellular proliferation and survival upon activation by their corresponding hormones. In cancers sensitive to hormonal cues, aberrant receptor signaling precipitates unchecked cellular proliferation, thereby fueling tumorigenesis. The molecular mechanisms underlying hormonal receptor activity in cancer involve complex signaling pathways and interactions with other cellular components. The dysregulation of these pathways can lead to resistance to conventional therapies and disease progression. Thus, targeted therapies that specifically inhibit hormonal receptor signaling have emerged as promising treatment options. Various strategies have been devised to target hormonal receptors in cancer. These include hormone receptor antagonists, which block receptor activation, and inhibitors of downstream signaling pathways involved in receptor-mediated tumorigenesis.
Therefore, the aim of this Special Issue, titled “The Role of Hormonal Receptors in Cancer: Molecular Mechanisms and Targeted Therapies”, is to provide novel insights into the molecular action of hormone receptors and new targeted therapies for human cancer. Contributions on these related topics are welcomed, including original research and reviews.
Dr. Laura Muñoz-Moreno
Guest Editor
Manuscript Submission Information
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Keywords
- hormone receptors
- cancer
- cell signaling
- cancer therapeutics
- cancer proliferation
- hormone-sensitive cancers
