Cell Apoptosis in Cancers: Regulation Factors

Dear Colleagues,

Apoptosis is a critical process in the prevention of cancer development. The regulation factors that control apoptosis play a significant role in determining whether cancer cells survive or die. Understanding these factors and how they influence cell death can provide valuable insights for developing new strategies for cancer treatment and prevention. One key factor in the regulation of apoptosis in cancer is the balance between pro-apoptotic and anti-apoptotic proteins. Pro-apoptotic proteins promote cell death, while anti-apoptotic proteins inhibit it. Disruption of this balance can lead to uncontrolled cell growth and the development of cancer. For example, mutations in the Bcl-2 family of proteins, which regulate apoptosis, have been associated with various types of cancer. Another important factor in the regulation of cell apoptosis in cancer is the activation of specific signaling pathways such as the PI3K/Akt pathway, can regulate cell survival and apoptosis. Dysregulation of these pathways can lead to resistance to cell death and contribute to cancer progression. Targeting these signaling pathways with specific inhibitors can be an effective strategy for inducing apoptosis in cancer cells. This Special Issue will discuss the recent advances in the field, thereby contributing to our knowledge on how the selective inclusion or exclusion of key signaling pathways play a role in signal transduction, apoptosis, and cancer development or treatment.

Dr. Shabnam Malik
Guest Editor

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• apoptosis
• regulation factors
• cell death
• cancer
• treatment