Recent Advances in Cancer Chemoprevention: Focus on Natural Product

Dear Colleagues,

Cancer is one of the most common and incurable diseases in humans, in spite of improved approaches to the detection and treatment of this pathology. Several pharmacological approaches have been developed (radiotherapy, chemotherapy, surgical intervention, target therapy) for the treatment of tumors and related metastasis; however, many counterproductive effects have been found, including multidrug resistance.

Several factors including unhealthy diet, cigarette smoking, alcohol consumption, environmental carcinogens exposure, stress, and physical inactivity, as well as hormonal factors, strictly correlate to cancer onset and dissemination. By contrast, a healthy diet coupled with the consumption of specific phytochemical compounds may play a protective role against tumor onset. According to this idea, the concept of “chemoprevention” has been recently introduced, a term that refers to natural compounds with the capability to hinder malignant transformation and dissemination with negligible side effects.

Thus, the main purpose of this Special Issue is to highlight the most relevant knowledge about the chemopreventive and antimetastatic properties of certain edible plants and fruits, as well as their extracts, emphasizing their interference with cellular and molecular events underlying tumor progression.

Dr. Domenica Mangieri
Guest Editor

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• natural compounds
• phytochemicals
• flavonoids
• alkaloids
• metastatic cascade
• apoptosis
• autophagy
• cell cycle
• drug resistance
• oxidative stress
• epithelial–mesenchymal transition
• signaling pathways