Molecular Mechanisms at the Intersection of Protein Synthesis, Cancer, and Immunity

Dear Colleagues,

Dysregulated protein synthesis is a common feature of malignancies. Tumor-associated perturbations in the expression and activity of the translation machinery have been repeatedly shown to impact the intrinsic traits and processes thought to drive aggressive phenotypes and poor outcomes in cancer patients. Recent advances have evidenced that the interface between tumors and the immune defenses (i.e., immune evasion vs. immune-mediated destruction) is impacted by the regulation of translation-level mechanisms. With several key molecular and cellular regulators of immune activity and suppression potentially under the sway of physiological and malignant translation, a better understanding of the interplay between translational control, immune regulation, and/or cancer progression may shed light on the failure of endogenous and therapy-induced anti-tumor immune responses, thus presenting opporunities for intervention.

In this Special Issue, we seek to compile original research articles, reviews, and case reports that expand on the compelling, but under-appreciated, intersection of translational control with immunoregulatory and cancer-promoting mechanisms. Highlighting this area of study, we aim to encourage mutlidisciplinary investigations to improve our understanding of the molecular mechanisms underlying immunity and cancer progression. The insights gained may uncover translation-relevant prognostic factors and candidate targets for therapy that may be used to personalize the care and treatment of patients with difficult-to-treat cancers.

Dr. Joseph Barbi
Dr. Sarah E. Walker
Guest Editors

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• translation
• protein synthesis
• immunology
• tumor
• cancer
• immune suppression
• initiation
• elongation
• eukaryotic initiation factors
• ribosome