Proteomics of Human Peripheral Blood Mononuclear Cells in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 198
Special Issue Editor
Interests: clinical proteomics; mass spectrometry; immune system; subsets of mononuclear cells; cancer; COVID-19; biomarkers
Special Issue Information
Dear Colleagues,
Clinical proteomics focuses on the comprehensive study of proteins in various clinical settings with the aim of enhancing our understanding of disease mechanisms, biomarker discovery, and personalized medicine. Mass spectrometry and other high-throughput proteomic techniques are commonly employed in the clinical proteomics of peripheral blood.
Peripheral blood mononuclear cells (PBMCs) are a heterogeneous population of immune cells that includes lymphocytes (T cells, B cells, NK cells), monocytes, and dendritic cells. Proteomics analysis of PBMCs provides insights into the immune system's status and its role in cancer diseases and conditions. Further therapeutic advances require a deeper understanding of the interplay between immune cells in peripheral blood and tumors. With such an in-depth understanding of pathology, the development of novel clinical biomarkers can proceed efficiently and effectively, leading to an enhanced likelihood of improving patient outcomes.
The aim of this Special Issue is to attract attention to experiments that characterize the proteome of peripheral blood mononuclear cells in cancer, which are highly valuable for the identification of clinically applicable and functionally relevant biomarkers, and to the resolution of pathological problems in cancer that have not yet been addressed.
Prof. Dr. Ján Sabo
Guest Editor
Manuscript Submission Information
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Keywords
- clinical proteomics
- cancer
- immune response
- peripheral blood mononuclear cells (PBMC)
- CD8+ T cells in PBMC
- CD4+ T cells in PBMC
- B cells in PBMC
- monocytes in PBMC
- NK cells in PBMC
- dendritic cells in PBMC
- biomarker discovery
