Oncoprotein Mechanisms: Prospects in Treatment

Dear Colleagues,

This Special Issue explores emerging findings in oncoproteins in terms of unraveling novel insights into cancer biology. Topics to be covered include the molecular mechanisms underlying the involvement of oncoproteins in cancer progression, their potential as diagnostic markers or therapeutic targets, recent advancements in understanding their interactions within the tumor microenvironment and the role of microsomes/exosomes in tumor biology. This collection aims to foster interdisciplinary discussions, bringing together researchers who push the boundaries of knowledge in harnessing recent knowledge for innovative approaches in cancer diagnosis and treatment.

SPECIFIC TOPICS

1. Molecular Mechanisms: Unraveling protein–protein interactions and signaling pathways

Investigations into molecular mechanisms stand at the forefront. Understanding how oncoproteins influence cancer progression requires a comprehensive exploration of the intricate signaling pathways they manipulate, but also of the key relayer of signaling: protein–protein interactions leading phenotypic switching, i.e., the alternative interactions they engage when they are mutated or overexpressed. Thus, unraveling the complex network of protein–protein interactions that underpin aberrant cellular signaling leading to cancerous growth is of crucial importance in identifying novel network targets.

Researchers aim to pinpoint key nodes in these networks where oncoproteins exert their influence. This detailed molecular dissection not only enhances our fundamental knowledge of cancer biology but also provides potential targets for therapeutic interventions. By discerning the molecular dance orchestrated by oncoproteins, scientists pave the way for more precise and effective strategies to combat cancer at its core.

2. Therapeutic Targeting: Navigating Toward Precision Medicine

An important avenue in cancer therapeutics revolves around not just the targeted disruption of oncoprotein activities but also, and more importantly, that of cancer networks. Equipped with insights into the molecular intricacies of oncoprotein-driven signaling pathways, researchers assess the feasibility of therapeutic interventions. The spotlight is on developing strategies that specifically target oncoprotein networks, aiming to dismantle the molecular machinery propelling cancerous growth.

Moreover, researchers delve into the roles of interacting oncoproteins in the context of drug addiction and resistance. Understanding how these proteins contribute to the evasion of therapeutic measures is paramount for refining treatment strategies. The quest for precision medicine in cancer therapy hinges on unraveling the specific vulnerabilities introduced by oncoproteins and tailoring interventions to exploit these weaknesses. As oncoproteins become prime targets for therapeutic endeavors, the landscape of cancer treatment is undergoing a paradigm shift towards more precise and effective strategies.

Dr. Nikolaos A. Papanikolaou
Guest Editor

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• oncoproteins
• cancer biology
• molecular mechanisms
• therapeutic targeting
• tumor microenvironment
• microsomes/exosomes