Cross-Talk between Mitochondrial Dysfunction and Neuroinflammation in Central Nervous System Disorders

Dear Colleagues,

Mitochondrial dysfunction and neuroinflammation have been linked to an array of brain disorders, from neurodevelopmental to neurodegenerative diseases such as autism spectrum disorders and Alzheimer’s and Parkinson’s disease, each characterized by distinct clinical manifestations and underlying pathological mechanisms. Both mitochondrial damage and the activation of neuroinflammatory pathways can mutually contribute to neuronal and synaptic dysfunction and thus to the progression of these apparently different diseases. On the one hand, mitochondria could be a pivotal element to the triggering of neuroinflammation through the release of damage-associated molecular patterns (DAMPs) that can stimulate various innate immune receptors to promote inflammation. On the other hand, the inflammatory factors released by activated glial cells might trigger specific signaling pathways which affect mitochondrial function. However, the cross-talk between mitochondrial dysfunction and neuroinflammatory activation is complex and not fully explained. Therefore, this Special Issue is designed to emphasize the link between mitochondrial dysfunction and neuroinflammation in different central nervous system (CNS) disorders. An in-depth understanding of the specific molecular mechanisms of mito-inflammation and the progression of neuroinflammation may contribute to the identification of new targets for the treatment of neuropsychiatric disorders. In this regard, we would like to encourage the submission of original papers providing new evidence on the connection between mitochondrial dysfunction and neuroinflammation in the etiology of brain disorders and review articles which address the above-mentioned topics.

Dr. Agata Adamczyk
Guest Editor

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• central nervous system
• mitochondria
• neuroinflammation
• neurodegenerative diseases
• neurodevelopmental disorders