P53: Mechanisms in DNA Damage Repair Responses and Roles in Cancer

Dear Colleagues,

Since its discovery forty-five years ago, p53 has solidified its status as a vital tumour suppressor, crucial for maintaining genome stability. Despite extensive research, understanding the intricate role of p53 in tumour initiation and progression remains a challenge.

This IJMS Special Issue aims to address critical questions raised in contemporary literature, such as the confusion surrounding p53 research, the perceived limitations of precision oncology involving p53-based therapies and the importance of DNA repair pathways in therapeutic contexts. Moreover, it aims to scrutinise the definition of cell death and its implications in cancer biology.

The purpose of this Special Issue is to shed light on the multifaceted roles of p53 in DNA damage responses. Authors are encouraged to explore the challenges associated with implementing p53-based therapies, including tumour heterogeneity and therapy resistance, as well as dormancy mechanisms, such as polyploid/multinucleated giant cells (PGCCs) and reversible senescence in the context of p53-mediated responses. Furthermore, this Special Issue aims to delve into apoptosis-related phenomena, including anastasis, Phoenix Rising and Treacherous Apoptosis, highlighting their impact on cancer progression. Original studies elucidating novel aspects of the p53 family protein and isoform function and investigations into the epigenetic mechanisms governing p53 regulation are also of interest.

In summary, this Special Issue seeks to update our understanding of complex roles of p53 in DNA damage responses and cancer pathogenesis. By addressing the current challenges and exploring novel avenues of research, it aims to pave the way for improved strategies in p53-based cancer therapy.

Dr. Luiza Steffens Reinhardt
Guest Editor

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• p53
• DNA damage response
• precision oncology
• therapy resistance
• tumor heterogeneity
• apoptosis
• anastasis
• PGCCs
• Phoenix Rising
• Treacherous Apoptosis